Posts tagged: antibiotics

How does Photodisinfection Work?

Photodisinfection is a topical, non-antibiotic antimicrobial therapy that destroys a broad spectrum of pathogens including fungi, bacteria and virus without damaging human tissue. Unlike antibiotics, Photodisinfection selectively kills virulence factors such as the endotoxins and exotoxins produced by pathogens, leading to a clinically observable anti-inflammatory effect. The treatment process takes only minutes, making it over 1,000 times more effective at biofilm killing than antibiotics.

Photodisinfection is a minimally invasive non-thermal therapy involving the light activation of a photosensitizer to eliminate topical infections in a highly targeted approach. Photodisinfection has been proven to be safe and effective in other applications such as for the dental, sinusitis and hospital acquired infection prevention markets. In dentistry, Photodisinfection has been proven to be highly effective for the treatment of caries, endodontics, restorative dentistry, periodontitis, peri-implantitis and halitosis. Many new applications of Photodisinfection are now under development.

The Photodisinfection Process: Instant Antimicrobial Therapy

Apply Photosensitizer to Infection Site & Illuminate with Appropriate Wavelength for Several Minutes

A photosensitizing solution is applied to the treatment site where the photosensitizer molecules preferentially bind to the targeted microbes.  The photosensitizer molecules are inactive at this stage.  A light of a specific wavelength and intensity illuminates the treatment site and a photocatalytic reaction occurs.  The wavelength is carefully chosen to maximize absorption of light energy by the photosensitizer.

This 2 step procedure results in the destruction of the targeted microbes and their virulence factors without damaging host cells.  This reaction involves the formation of short-lived, highly reactive free-radical oxygen species.  These radicals cause a physical disruption of the microbial cell membrane through oxidative reactions, resulting in immediate rupture and destruction of the cell.  This process occurs in seconds with total kills completed in minutes.

The Photodisinfection process has also been shown to eliminate a multitude of virulence factors, unlike antibiotics. When the light isremoved, the photocatalytic reaction ceases along with all antimicrobial action. Photodisinfection does not promote the development of resistance.

The Photodisinfection process is both pain-free and stress-free due to lack of side-effects or damage to human tissue.

Source: Eastman Dental Institute, UK

Scaling and Root Planing Isn’t Always Enough to Treat Gum Disease

SRP is not always 100% effective. Calculus and bacteria can be left behind.

Dental scaling and root planing, known as SRP, is often used when a straightforward cleaning isn’t enough, and is sometimes called deep cleaning. This nonsurgical procedure aims to remove the plaque and calculus or tartar which has built up around and just under the gum line by scaling or scraping the teeth. The process can help leave nice smooth surfaces enabling the gum tissue to attach more firmly to the surface of the tooth, and is one of the most common therapies used to treat gum disease1.

While SRP is often regarded as being the gold standard in the treatment of gum disease, it isn’t always 100% effective. Part of the problem is due to the fact that the clinician cannot generally see the calculus below the gum line, and must rely on their sense of touch to scrape away the calculus. This lack of visual feedback heightens the chance some small areas of calculus being inadequately removed. When gum disease is left improperly treated, the patient can experience tissue inflammation, gum recession, and even bone loss. Not only can this put the patient’s overall health at risk, but it can also allow the gum disease to worsen to a point where it requires additional treatments. Read more »

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