Periowave: A Unique Anti-Inflammation Therapy that Yields Superior Patient Outcomes

It is widely understood that chronic periodontitis is due to the presence of subgingival Gram-negative bacterial biofilms proliferating at the junctional epithelium, in periodontal pockets deep beneath the gumline. Mechanical debridement (scaling) and root planing (SRP) is standard therapy for chronic periodontitis. While SRP is useful for the removal of the calculus, SRP unfortunately leaves the majority of the Gram-native biofilm in the periodontal pocket resulting in the need for retreatment every 3 months to control the disease. SRP alone is often inadequate for very deep pockets, for instance pockets that are 10-13 millimetres deep. Patients with deep periodontal pockets typically are referred to specialists for surgical intervention, especially when bone loss is evident. Photodisinfection is a non-antibiotic, light based therapy that offers a non-invasive alternative to surgery. Photodisinfection has been shown to instantly inactivate the Gram-negative bacteria associated with periodontal diseases, as well as the bacterial virulence factors responsible for triggering inflammation.  The key virulence factors of P. gingivalis (a primary perio-pathogen) include the cytotoxin lipopolysaccharide (“bacterial endotoxin or LPS”), proteolytic enzymes and many toxic low-molecular weight compounds such as hydrogen sulfide and ammonia.  The proteases in particular are thought to be responsible for the majority of periodontal tissue damage.  Photodisinfection destroys the LPS and other virulence factors, a significant advantage over conventional antibiotics and antiseptics. Periowave Photodisinfection, more importantly, offers a key advantage over other therapies as it was able to demonstrate direct and immediate inactivation pro-inflammatory cytokines. The Periowave Photodisinfection approach can directly inhibit LPS, reducing the risk of cytotoxic shock, and can substantially reduce protease activity, minimizing the risk of further tissue damage. Periodontal (gum) disease is a chronic disease affecting about half the adult population.  It is the leading cause of tooth loss, responsible for about two thirds of lost teeth.  Pain and cost factors result in the majority of diagnosed patients neglecting to address their gum disease. Periowave Photodisinfection technology, with its unique ability to simultaneously eliminate the underlying bacteria causing chronic gum disease as well as reduce inflammation, is an important stress free therapy benefitting both the patient and the dental clinician.  Periowave is a cost effective and pain-free approach to the treatment of gum disease, whether as a prevention therapy in early stages of the disease or as a possible alternative to surgery in later stages of the disease. Irrigate Illuminate To learn more about Periowave Photodisinfection, please visit www.periowave.com

Periowave Photodisinfection- The Unique 3 Prong Attack on Periodontal (Gum) Disease

The most common of human infections is gum (or periodontal) disease, affecting up to 80% of the population at some point in their lives. The primary issue is that teeth are non-shedding surfaces and so bacteria, in the form of biofilms, can easily establish themselves on the surface of a tooth where tooth-brushing or other mechanical debridement is lacking.

Gum disease is caused by the presence of gram-negative bacterial biofilms growing in the periodontal pockets underneath the gum line. These gram- negative pathogens associated with gum disease are largely anaerobic, thriving in environments with little to no oxygen. Bacteria, and their associated virulence factors, cause an immune response by the body. Gram negative pathogens associated with gum disease are not “good” bugs (commensals), that is, they are not part of the body’s natural flora. One pathogen, Porphyromonas  gingivalis, according to Dr. Richard Darveau, Dean  of the University of Washington’s Dental School, has demonstrated an ability to modify the behaviour of oral commensals, turning bacteria that are normally ‘good’ bacteria into ‘bad’.  Perio-pathogens,  such as Porphyromonas  gingivalis, up-regulate the body’s production of proteolytic enzymes, cytokines and other pro-inflammatory factors in order to sustain their continued growth. The result is inflammation with widespread impact on the local as well as systemic physiology.

Gum disease has been associated with a number of serious systemic conditions including heart disease, stroke, diabetes, pre-diabetes, cancer, Alzheimer’s and pre-term births. The most notable local symptoms of the effects of these perio-pathogens  are red inflamed gums and the loss of alveolar bone supporting the teeth. Gum disease is responsible for about two thirds of tooth loss. Scaling and root planing (SRP), the historic standard of care leaves as much as 60% of the perio-pathogens behind to continue the disease process, which is why the SRP protocol requires a 3 month retreatment recall program. Photodisinfection, however, has been able to double the outcomes of SRP in clinical trials.

Effective gum disease eradication requires 3 components which only Periowave Photodisinfection provides: the instantaneous elimination of virtually all of the gram negative anaerobic perio-pathogens, the destruction of their associated virulence factors, and the inactivation of the host inflammatory factors. When removing both the biofilm and the inflammation simultaneously, the body is then able to repair itself through soft and hard tissue regeneration.  Periowave Photodisinfection has been proven to rapidly and effectively kill the micro-organisms located in periodontal biofilms and to destroy the virulence factors produced by these pathogens. Most importantly, Periowave has a unique advantage, an ability to rapidly and substantially reduce protease activity, providing a high-level suppression of pro-inflammatory cytokines needed to restore oral health.

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